SarahVaughter
October 20th, 2009, 09:32 AM
We get a lot of questions about Lufenuron dosing. How to dose accurately, whether the dose we supply is sufficient, etc.
We have done a great deal of scientific literature research to arrive at the current dose (15 grams) and dosing regime (taking it over 5 days, 3 grams a day). We studied the animal trials, the safety tests and the chemical properties of Lufenuron.
Q: How to accurately take 3 grams of Lufenuron a day, and is 15 grams over 5 days enough?
A: No need to try to dose accurately. You could even take everything in one single dose, but that poses a risk of poor absorbtion. This is why animal studies recommend spreading it over a few days. The Lufenuron does NOT kill the Candida in the days you take it. It kills the Candida AFTER you took it, because Lufenuron is first absorbed by your fat tissues, and then slowly released over the month that follows. During that time, every tissue with blood flowing through it will be exposed to Candida-killing Lufenuron concentrations.
So do not worry or bother trying to accurately divide the 15 grams we send you into equal 3-gram portions. It is totally unnecessary. It is completely irrelevant whether you would take 5 grams on the first day, 2 on the second, 4 on the third, 3 on the forth and 1 on the fifth, because this would ensure an overall good absorbtion of those 15 grams of Lufenuron into your fat tissues. 15 grams in one go is a bit risky if your meal has not enough fat in it or if you'd have digestive problems. That's all there is to it. But do not spreak it out over more than 5 days - less is OK, more not!
Lufenuron has a biological tissue half-life of approx. 10 days. This is why at the end of the 5 days, the concentration in your body will be at its highest and only very slowly diminish over the weeks that follow. This is a unique property of Lufenuron, this is how a 30-kilo (60 lbs) dog can remain flea-free for an entire month by just taking one single 408 mg Lufenuron tablet, a dose of around 14 mg/kg. We sell 15 gram amounts. A person weighing 100 kg / 200 lbs will therefore attain a tissue concentration of 150 mg/kg body weight at the end of those 5 days. This is several times more than in successful animal tests, where chimpanzees were cured of fungal infections.
This is how we explained it in a recent email to a customer:
Hi ***,
It's just a misunderstanding about how those animal trials went, and about the half-life of Lufenuron :-) They gave the animals one single dose and don't spread it over multiple days.
Lufenuron, due to its enormous biological half-life, is "loaded" into the tissues over a period of 5 days.
But its half-life is about ten days.
If we do the numbers:
You received 15 000 mg and weigh 82 kg.
Because Lufenuron has such a long half-life, this means you are using 15000 / 82 = 182 mg/kg.
In fact, due to absorbtion and half-life issues, I estimate it will be around 150 mg/kg for you, on the end of day 5.
We dose this way (5 days) and in this quantity (15 grams) exactly to give people an even higher dose per kilo than in the animal trials. We studied the medical literature (the trials) and found that spreading over 5 days gave better results than taking the entire dose in one go, assumedly due to absorbtion issues.
Hope this clears it up!
Your question is very important however, and we will put it (anonymously) on the forum in case others have similar concerns.
Again, those animals got **one single dose of Lufenuron**, _not_ over 5 days. Lufenuron's half-time is even longer than 5 days. So at the end of 5 days, your tissues are exposed to more than 100 mg/kg. Dogs that weigh 30 kilo take one single 408 mg tablet for one month flea protection, you take 36 / (82 / 30) = 13 times more per kilo than used in flea control.
So if this doesn't work, raising the dose won't help much. Our dosing schedule is based on the successful animal trials, and then we added more, just to be sure that the heaviest people would fall into that category.
Best regards,
Sarah
-----Original Message-----
From: ******@*******.net [mailto:******@*******.net]
Sent: 20. october 2009 01:39
To: sarah@owndoc.com
Subject: Lufenuron dosage
I received my packet of lufenuron and am on the third day of use. In browsing the web, I have noticed that some people who got it through vets took up to 100 mg per kg of weight, and some of the animal (cats and dogs) antifungal trials were on the order of 50 mg per kg or more. The 15g that I am taking over five days amounts to about 18 mg per kg for me (I weigh 82 kg). How did you and your husband arrive at the dosage that you suggest? Have you had any customers take multiples of this dosage? (I don't mean repeat administrations, just heavier dosages.) I understand that for flea control, 10mg per kg is standard, but for fungal control greater dosages seem to have been used. I would be willing to order more and take a greater dose, unless you feel that would be needless.
Thanks.
*** ********
Fort Worth, TX, USA
We have done a great deal of scientific literature research to arrive at the current dose (15 grams) and dosing regime (taking it over 5 days, 3 grams a day). We studied the animal trials, the safety tests and the chemical properties of Lufenuron.
Q: How to accurately take 3 grams of Lufenuron a day, and is 15 grams over 5 days enough?
A: No need to try to dose accurately. You could even take everything in one single dose, but that poses a risk of poor absorbtion. This is why animal studies recommend spreading it over a few days. The Lufenuron does NOT kill the Candida in the days you take it. It kills the Candida AFTER you took it, because Lufenuron is first absorbed by your fat tissues, and then slowly released over the month that follows. During that time, every tissue with blood flowing through it will be exposed to Candida-killing Lufenuron concentrations.
So do not worry or bother trying to accurately divide the 15 grams we send you into equal 3-gram portions. It is totally unnecessary. It is completely irrelevant whether you would take 5 grams on the first day, 2 on the second, 4 on the third, 3 on the forth and 1 on the fifth, because this would ensure an overall good absorbtion of those 15 grams of Lufenuron into your fat tissues. 15 grams in one go is a bit risky if your meal has not enough fat in it or if you'd have digestive problems. That's all there is to it. But do not spreak it out over more than 5 days - less is OK, more not!
Lufenuron has a biological tissue half-life of approx. 10 days. This is why at the end of the 5 days, the concentration in your body will be at its highest and only very slowly diminish over the weeks that follow. This is a unique property of Lufenuron, this is how a 30-kilo (60 lbs) dog can remain flea-free for an entire month by just taking one single 408 mg Lufenuron tablet, a dose of around 14 mg/kg. We sell 15 gram amounts. A person weighing 100 kg / 200 lbs will therefore attain a tissue concentration of 150 mg/kg body weight at the end of those 5 days. This is several times more than in successful animal tests, where chimpanzees were cured of fungal infections.
This is how we explained it in a recent email to a customer:
Hi ***,
It's just a misunderstanding about how those animal trials went, and about the half-life of Lufenuron :-) They gave the animals one single dose and don't spread it over multiple days.
Lufenuron, due to its enormous biological half-life, is "loaded" into the tissues over a period of 5 days.
But its half-life is about ten days.
If we do the numbers:
You received 15 000 mg and weigh 82 kg.
Because Lufenuron has such a long half-life, this means you are using 15000 / 82 = 182 mg/kg.
In fact, due to absorbtion and half-life issues, I estimate it will be around 150 mg/kg for you, on the end of day 5.
We dose this way (5 days) and in this quantity (15 grams) exactly to give people an even higher dose per kilo than in the animal trials. We studied the medical literature (the trials) and found that spreading over 5 days gave better results than taking the entire dose in one go, assumedly due to absorbtion issues.
Hope this clears it up!
Your question is very important however, and we will put it (anonymously) on the forum in case others have similar concerns.
Again, those animals got **one single dose of Lufenuron**, _not_ over 5 days. Lufenuron's half-time is even longer than 5 days. So at the end of 5 days, your tissues are exposed to more than 100 mg/kg. Dogs that weigh 30 kilo take one single 408 mg tablet for one month flea protection, you take 36 / (82 / 30) = 13 times more per kilo than used in flea control.
So if this doesn't work, raising the dose won't help much. Our dosing schedule is based on the successful animal trials, and then we added more, just to be sure that the heaviest people would fall into that category.
Best regards,
Sarah
-----Original Message-----
From: ******@*******.net [mailto:******@*******.net]
Sent: 20. october 2009 01:39
To: sarah@owndoc.com
Subject: Lufenuron dosage
I received my packet of lufenuron and am on the third day of use. In browsing the web, I have noticed that some people who got it through vets took up to 100 mg per kg of weight, and some of the animal (cats and dogs) antifungal trials were on the order of 50 mg per kg or more. The 15g that I am taking over five days amounts to about 18 mg per kg for me (I weigh 82 kg). How did you and your husband arrive at the dosage that you suggest? Have you had any customers take multiples of this dosage? (I don't mean repeat administrations, just heavier dosages.) I understand that for flea control, 10mg per kg is standard, but for fungal control greater dosages seem to have been used. I would be willing to order more and take a greater dose, unless you feel that would be needless.
Thanks.
*** ********
Fort Worth, TX, USA