Lufenuron for an underweight guy?

[nick_charles]

From the materials on this site, I know that Lufenuron works by being taken up by the fat stores of the body and then is slowly released over time.

Would being underweight impair that mechanism? I don't know how much fat I have, but I'm 6'2" and 115 lbs., a BMI just under 15.

Does ketosis interfere with the mechanism? Candida has forced me to drop most carbs from my diet.

Any insights you have would be appreciated!

Nick

[SarahVaughter]

Ketosis could indeed possibly interfere - we do not know to be honest but suspect that absorbtion could indeed be sub-optimal.
I'll let John look into it and update the user manual.

Low body fat should be no problem all the way down to 6%, as long as you have fat (and are not in ketosis, perhaps..)

You're not the first one to ask. I always say that to be sure, don't be in ketosis during at least the loading days.

[nick_charles]

Thanks for the quick response. I'll eat some sweet potatoes on the loading days (and the days leading up to them). Should I scale down the dosage for my weight, or go with the 165 lb. orangutan guideline to cover the possibility of suboptimal absorption?

Also, I noticed that the previous loading period was five days with more lufenuron. What prompted the change?

[SarahVaughter]

We changed dose, price & loading time due to more feedback data from customers. The previous dose was a tad too high, we shouldn't overdo it with dosing either.

In principle, a single loading day is enough. Five days is a little too excessive. Based on medical trial literature, 15 grams was sufficient for a very, very heavy person (far into morbidly obese) so we decided to choose 9 grams.

Regardless of your weight (unless you are very light), I'd take 9 grams because the chance of a full recovery is dosage-dependent.

You may have noticed that we also had to change the price, due to the fact that for a period we could not find sufficiently pure Lufenuron and we have to pay a premium for premium quality nowadays.

[nick_charles]

Believe me, what I've paid for all the (ineffectual!) anti-candida formulas and remedies absolutely dwarfs whatever you choose to charge for Lufenuron.

Is it better to wait between rounds of Lufenuron, or to re-dose after the end of the three weeks? (My candida infection likely stems from unusually heavy antibiotic use in early childhood, so I'm guessing it won't give up easily.)

Lastly, do you know what other fungi, parasites, etc., contain chitin (or are otherwise affected by Lufenuron)?

Thanks for the prompt -- yet thorough -- answers!

[SarahVaughter]

Not many parasites contain chitin but many fungal species do, but not all, e.g. Tinea fungi are unaffected by Lufenuron due to the fact that they do not use Chitin.

Semi-systemic Candidiasis is in our opinion incurable. The disease remains with you for life, even if you'd been on IV antifungals for a year. All you can do is become (nearly) symptom free for 99% of the time, and that involves the two-pronged approach of a heroic onslaught of antifungal medicines (as in years of antifungal cocktails) and boosting the immune system or at least avoiding damage to it.

My husband still has pink spots on his penis and still has sores under his foreskin when he has had a few bad nights' sleep. And he has been on IV Ampothericin B. Candida is incurable when it has become mycelial, but it is essential to use a variety of antifungals to prevent it from invading more organs than just deep inside the mucous membranes and warm, moist skin.

To treat any infection, you'd need to keep tissue levels above MIC at all times. (Minimum inhibitory concentration).

[nick_charles]

I don't have a good grasp of what qualifies as "semi-systemic"; would you explain it?

Does candida become mycelial over time, or when the immune system is weakened enough, or by something else entirely? And how does one tell if it's become mycelial?

[SarahVaughter]

Candida in yeast form is visible as a white pasty coating, sometimes odorous.

After some time (it can take weeks or years, depending mainly on immune system status but also on blood sugar levels and hygiene), the immune system does not manage to kill the yeasts off quickly enough to prevent them from growing roots into the mucous membranes, at which point the infection has become "mycelial" and for some complex immune-modulatory reasons, the yeast will disappear. This transition often is accompanied with a high fever and severe weakness.

Mycelial Candida is the Candida with all the serious symptoms such as painful sores and much worse.

Systemic Candida is an extremely lethal infection that not many survive, not even when they're in a hospital, receiving intravenous antifungals. Death comes in mere days. Without treatment, nearly 100% of cases are lethal in just a few days (as in three, four days). 1000 yeast cells, injected into a vein, are the LD50 dose (half the people would die). This is based on animal experiments.

Even when you are very ill with Candida, if you can still type on a keyboard or if you had it for longer than a few hours and you can still stand, you don't have systemic Candida but something I call semi-systemic Candida. Systemic means that it's in one or more organs - always lethal without prompt, heroic treatment - and with semi-systemic I mean that it's all over your mucous membranes, including, in some cases, in the lining of the colon. The eyes, throat, cheeks, lips, sex organs all can be severely affected and the patient can be very ill. Such a state can turn into a systemic infection but I do not know how often that happens.

Semi-systemic Candidiasis is nearly impossible to get rid of. And even when you manage to become nearly symptom-free (which can take years and often requires long-term antifungal treatment with prescription antifungal medicines), you will still have mild symptoms when you neglect intimate hygiene, oral hygiene or even when you've been walking for a few hours in sweaty jogging pants.

Apart from sores, rashes and discolored skin (pinkish), mycelial Candida is invisible. It is not associated with white yeast plaques.

Semi-systemic Candidiasis is a problem often associated with long-term use of antibiotics of different families, and of an impaired immune system. Especially when both conditions are satisfied, such as long-term antibiotics against Lyme disease. Lyme disease often causes insomnia, which severely depresses the immune system.