SarahVaughter
February 7th, 2010, 11:00 AM
>I bought some Lufenuron from you early in October, having been told about it by
>Dr [deleted]
>[deleted] and I had been discussing how my Crohn's disease symptoms (loose
>stool) always improve when I take antifungal medication, something I discovered
>by accident. So [deleted] said I might like to be her first guinea-pig and try
>Lufenuron and see if that helped. I read the material on your website, decided to
>give it a go and took my first dose 9-12 October. The first few days I also was
>taking Nystatin but stopped so as to test the Lufenuron on its own. Symptoms
>stayed good. My blood indicator for my Crohn's inflammation is plasma
>viscosity. I happened to get it tested when I started Lufenuron and now, just
>over a month later. Thought you might like to know the result.
>Plasma Viscosity reference range 1.50-1.72
>March 09 2.08
>6 June 09 1.91
>12 Oct 09 2.13
>18 Nov 09 1.89
>The June result followed taking Fluconazole for 1 month during April/May,
>followed by Nystatin. In July August I was taking only VSL#3 probiotics, not
>anti-fungals but also after I broke my collarbone with complications I had a lot of
>pain meds which in turn required meds for constipation , unsettled my guts and
>worsened everything. I had allowed 3 weeks after stopping all pain meds for
>things to settle down but they hadn't. Beginning of October I had a short
>course(5 days) of Fluconazole and started taking Nystatin again but then
>switched to Lufenuron.
>So it looks to me like this is objective evidence of the Lufenuron working. But I
>got little in the way of die-off effect. As I was being a guinea pig, I kept a journal
>to track symptoms; a copy is attached. I might add that this was also a period of
>considerable stress in my life and I still got the improvement.
>Thank you so much for sharing your discovery of Lufenuron for candida, and for
>your website - so much commonsense. I had seen so many nutritional
>practitioners without success; I never felt worse when I ate yeast or funghi, only
>if I ate a lot of sugar - which I rarely did, so I was beginning to accept my
>orthodox GP's opinion that candidiasis was a myth.
First of all: I am by no means a medical doctor and my opinion is the opinion of a layperson.
I think Crohns is a symptom, not an illness. Meaning, the illness is not some mysterious autoimmune disorder that deserves its own name, but the manifestation of an infection (I assume a bacterial infection in most, since certain broadspectrum antibiotics usually help).
However, observing changes/improvement in the patient’s own body by the patient themselves is perhaps the most reliable way of finding out whether something helps – which would indirectly point to the etiology, the source of the problem. If you improve taking antifungal medicine, it may either be because your problems are primarily fungal, or because a bacterial infection caused an overgrowth of opportunistic fungi – something that can easily happen with a chronically damaged intestinal lining, which I am assuming you’re suffering from. For that to happen – assuming that Crohn’s is not AUTO-immune – I don’t believe in the “autoimmune” but in the plain “immune” theory – you must have a raging infection / inflammation going on, bec. the intestinal lining renews itself quickly and continuously.
I do not think your plasma viscosity values are statistically significant, neither do I think your journal shows evidence that the Lufenuron helped you (I am being ruthlessly honest both to you and to myself – we don’t peddle miracle cures, we are only interested in helping people, not in selling a lot of Lufenuron to anybody and everybody).
So you could have a “bacterial” Crohns or a fungal IBS or a combination of both, or even something else altogether. It is unfortunately difficult to obtain an accurate diagnosis, also because tests (WB, ELISA, immunofluorescence etc.) are (deliberately, for various reasons having to do with patents, politics and money) flawed. I will write an in-depth article about that later.
Experimenting with antibiotics can be dangerous when not done carefully – Candida infections may result. Experimenting with antifungals may lead to rapid resistance occuring in the fungus one is infected with.
I would advise you to continue Lufenuron for one more month and see whether you again experience an improvement. You should try to combine it with other antifungals, if possible, for synergy. This synergy is well-documented in peer-reviewed medical literature, and can even overcome built-up resistance.
After that trial, I would try Doxycycline (per oral) for a month, 200 mg/day, 100 mg taken with a meal, so you take them twice a day with the largest meals (after eating the meal). Doxy’s half-time is very long so you do not have to worry about timing. It’s winter, so sun-sensitivity is not a problem (stay out of the tanning studio!) If you are obese or a very large woman, take 300 mg/day or even 400 mg/day. Talk this over with your GP, perhaps she is willing to experiment with this.
Practice meticulous oral hygiene when doing this. Use a pH neutral soap. By no means use other antibiotics during this period and half a year afterwards, especially not Tinidazole or Metronidazole (Flagyl & Fasigyn). Candida WILL result if you do this, especially if you use different classes of abx. Together, such as Amoxicillin or Azithromycin. Take ONLY Doxy when you do this, and no antibiotic at all whatsoever. That’s my suggestion as a layperson. I could be totally wrong. If you feel better during that month, you can and perhaps should continue.
Spiroplasms and mycoplasms can be killed in the bowel, but they will likely retreat into your CNS and synovial fluid (joint cartelage), which are immune-compromised sites, meanignthat the immune system cells can't reach there. You may get cured of your Crohns, but get a mild arthritis or fatigue in return. Perhaps you already have these symptoms. If you have some occasional transient arthritic symptoms, that would point to an infectious etiology (cause), is my idea. Perhaps bacterial. Just my two cents, for what they are worth. I think most serious health problems, absent nutritional or genetic causes, is infectious of origin and I think that most illnesses (CFS, ME, MS, Crohns) are of infectious origin.
>Dr [deleted]
>[deleted] and I had been discussing how my Crohn's disease symptoms (loose
>stool) always improve when I take antifungal medication, something I discovered
>by accident. So [deleted] said I might like to be her first guinea-pig and try
>Lufenuron and see if that helped. I read the material on your website, decided to
>give it a go and took my first dose 9-12 October. The first few days I also was
>taking Nystatin but stopped so as to test the Lufenuron on its own. Symptoms
>stayed good. My blood indicator for my Crohn's inflammation is plasma
>viscosity. I happened to get it tested when I started Lufenuron and now, just
>over a month later. Thought you might like to know the result.
>Plasma Viscosity reference range 1.50-1.72
>March 09 2.08
>6 June 09 1.91
>12 Oct 09 2.13
>18 Nov 09 1.89
>The June result followed taking Fluconazole for 1 month during April/May,
>followed by Nystatin. In July August I was taking only VSL#3 probiotics, not
>anti-fungals but also after I broke my collarbone with complications I had a lot of
>pain meds which in turn required meds for constipation , unsettled my guts and
>worsened everything. I had allowed 3 weeks after stopping all pain meds for
>things to settle down but they hadn't. Beginning of October I had a short
>course(5 days) of Fluconazole and started taking Nystatin again but then
>switched to Lufenuron.
>So it looks to me like this is objective evidence of the Lufenuron working. But I
>got little in the way of die-off effect. As I was being a guinea pig, I kept a journal
>to track symptoms; a copy is attached. I might add that this was also a period of
>considerable stress in my life and I still got the improvement.
>Thank you so much for sharing your discovery of Lufenuron for candida, and for
>your website - so much commonsense. I had seen so many nutritional
>practitioners without success; I never felt worse when I ate yeast or funghi, only
>if I ate a lot of sugar - which I rarely did, so I was beginning to accept my
>orthodox GP's opinion that candidiasis was a myth.
First of all: I am by no means a medical doctor and my opinion is the opinion of a layperson.
I think Crohns is a symptom, not an illness. Meaning, the illness is not some mysterious autoimmune disorder that deserves its own name, but the manifestation of an infection (I assume a bacterial infection in most, since certain broadspectrum antibiotics usually help).
However, observing changes/improvement in the patient’s own body by the patient themselves is perhaps the most reliable way of finding out whether something helps – which would indirectly point to the etiology, the source of the problem. If you improve taking antifungal medicine, it may either be because your problems are primarily fungal, or because a bacterial infection caused an overgrowth of opportunistic fungi – something that can easily happen with a chronically damaged intestinal lining, which I am assuming you’re suffering from. For that to happen – assuming that Crohn’s is not AUTO-immune – I don’t believe in the “autoimmune” but in the plain “immune” theory – you must have a raging infection / inflammation going on, bec. the intestinal lining renews itself quickly and continuously.
I do not think your plasma viscosity values are statistically significant, neither do I think your journal shows evidence that the Lufenuron helped you (I am being ruthlessly honest both to you and to myself – we don’t peddle miracle cures, we are only interested in helping people, not in selling a lot of Lufenuron to anybody and everybody).
So you could have a “bacterial” Crohns or a fungal IBS or a combination of both, or even something else altogether. It is unfortunately difficult to obtain an accurate diagnosis, also because tests (WB, ELISA, immunofluorescence etc.) are (deliberately, for various reasons having to do with patents, politics and money) flawed. I will write an in-depth article about that later.
Experimenting with antibiotics can be dangerous when not done carefully – Candida infections may result. Experimenting with antifungals may lead to rapid resistance occuring in the fungus one is infected with.
I would advise you to continue Lufenuron for one more month and see whether you again experience an improvement. You should try to combine it with other antifungals, if possible, for synergy. This synergy is well-documented in peer-reviewed medical literature, and can even overcome built-up resistance.
After that trial, I would try Doxycycline (per oral) for a month, 200 mg/day, 100 mg taken with a meal, so you take them twice a day with the largest meals (after eating the meal). Doxy’s half-time is very long so you do not have to worry about timing. It’s winter, so sun-sensitivity is not a problem (stay out of the tanning studio!) If you are obese or a very large woman, take 300 mg/day or even 400 mg/day. Talk this over with your GP, perhaps she is willing to experiment with this.
Practice meticulous oral hygiene when doing this. Use a pH neutral soap. By no means use other antibiotics during this period and half a year afterwards, especially not Tinidazole or Metronidazole (Flagyl & Fasigyn). Candida WILL result if you do this, especially if you use different classes of abx. Together, such as Amoxicillin or Azithromycin. Take ONLY Doxy when you do this, and no antibiotic at all whatsoever. That’s my suggestion as a layperson. I could be totally wrong. If you feel better during that month, you can and perhaps should continue.
Spiroplasms and mycoplasms can be killed in the bowel, but they will likely retreat into your CNS and synovial fluid (joint cartelage), which are immune-compromised sites, meanignthat the immune system cells can't reach there. You may get cured of your Crohns, but get a mild arthritis or fatigue in return. Perhaps you already have these symptoms. If you have some occasional transient arthritic symptoms, that would point to an infectious etiology (cause), is my idea. Perhaps bacterial. Just my two cents, for what they are worth. I think most serious health problems, absent nutritional or genetic causes, is infectious of origin and I think that most illnesses (CFS, ME, MS, Crohns) are of infectious origin.